a protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at S62 by MASTL during mitosis, specifically interacts with PPP2R2D and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP43 expression. Interacts with SNCA. Two isoforms of the human protein, ARPP-19 and ARPP-16, are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Phosphatase, regulatory subunit