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CTNNG Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma- catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSC2. Belongs to the beta-catenin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: catenin complex; cell-cell adherens junction; cornified envelope; cytoplasm; cytoskeleton; cytosol; desmosome; extracellular matrix; extracellular region; focal adhesion; hemidesmosome; intercellular junction; internal side of plasma membrane; nucleus; plasma membrane; zonula adherens
Molecular Function: alpha-catenin binding; cadherin binding; cell adhesion molecule binding; protein binding; protein homodimerization activity; protein phosphatase binding; structural constituent of cell wall; transcription coactivator activity
Biological Process: cell migration; cell-cell adhesion; detection of mechanical stimulus; keratinization; neutrophil degranulation; positive regulation of protein import into nucleus; positive regulation of transcription factor activity; regulation of cell proliferation
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 12; Naxos Disease
Reference #:  P14923 (UniProtKB)
Alt. Names/Synonyms: ARVD12; catenin (cadherin-associated protein), gamma (80kD); catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; CTNNG; Desmoplakin III; Desmoplakin-3; DP3; DPIII; gamma-catenin; Junction plakoglobin; JUP; PDGB; PKGB; PLAK
Gene Symbols: JUP
Molecular weight: 81,745 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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