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ENSA a protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Specifically interacts with PPP2R2D (PR55-delta) during mitosis and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. May be associated with type 2 diabetes. Nine alternatively spliced human isoforms have been observed. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: cytoplasm; nucleoplasm
Molecular Function: ion channel inhibitor activity; phosphatase inhibitor activity; potassium channel inhibitor activity; protein binding; protein phosphatase 2A binding; protein phosphatase inhibitor activity; protein phosphatase regulator activity; receptor binding
Biological Process: G2/M transition of mitotic cell cycle; mitotic cell cycle; negative regulation of protein amino acid dephosphorylation; regulation of insulin secretion; response to nutrient; transport
Reference #:  O43768 (UniProtKB)
Alt. Names/Synonyms: Alpha-endosulfine; ARPP-19e; endosulfine alpha; ENSA; MGC4319; MGC78563; MGC8394
Gene Symbols: ENSA
Molecular weight: 13,389 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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