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MIG-6 Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. Interacts with ERBB2. Interacts with EGFR. Levels are very low in quiescent cells. Up-regulated by mitogens. Belongs to the MIG6 family. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Tumor suppressor
Chromosomal Location of Human Ortholog: 1p36.23
Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane
Molecular Function: GTPase activator activity; protein binding; protein kinase binding
Biological Process: alveolus development; negative regulation of epidermal growth factor receptor activity; negative regulation of protein amino acid autophosphorylation; regulation of keratinocyte differentiation; response to stress; skin morphogenesis
Reference #:  Q9UJM3 (UniProtKB)
Alt. Names/Synonyms: ERBB receptor feedback inhibitor 1; ERRFI; ERRFI1; GENE-33; MIG-6; MIG6; Mitogen-inducible gene 6 protein; RALT; receptor-associated late transducer
Gene Symbols: ERRFI1
Molecular weight: 50,560 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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