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COX-1 May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - arachidonic acid; Oxidoreductase
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component: cytoplasm; endoplasmic reticulum membrane; Golgi apparatus; intracellular membrane-bound organelle; nucleus
Molecular Function: peroxidase activity; prostaglandin-endoperoxide synthase activity
Biological Process: cyclooxygenase pathway; prostaglandin biosynthetic process; regulation of blood pressure; xenobiotic metabolic process
Reference #:  P23219 (UniProtKB)
Alt. Names/Synonyms: COX-1; COX1; cyclooxygenase-1; Cyclooxygenase-1; PCOX1; PGG/HS; PGH synthase 1; PGH1; PGHS-1; PGHS1; PHS 1; PHS1; Prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); PTGHS; PTGS1; RP11-542K23.6
Gene Symbols: PTGS1
Molecular weight: 68,686 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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