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PUMA essential mediator of p53-dependent and independent apoptosis. Binds to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Interacts with BCL2, BCL2L1, MCL1 and BCL2A1. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53. Regulates ER stress-induced neuronal apoptosis. Induced by DNA damage, glucocorticoid treatment, growth factor deprivation and p53. Ubiquitously expressed. Ubiquitously expressed. Belongs to the Bcl-2 family, BH3-only pro-apoptotic subclass. Four isoforms of the human protein are apparently produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Mitochondrial
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: lysosome; mitochondrion
Molecular Function: ATPase binding; glycoprotein binding; protein binding
Biological Process: apoptosis
Reference #:  Q9BXH1 (UniProtKB)
Alt. Names/Synonyms: BBC3; Bcl-2-binding component 3; BCL2 binding component 3; FLJ42994; JFY-1; JFY1; p53 up-regulated modulator of apoptosis; PUMA
Gene Symbols: BBC3
Molecular weight: 20,532 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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