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OS9 Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. Belongs to the OS-9 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 12q13.3-q14.1
Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum membrane
Molecular Function: glycoprotein binding; protein binding
Biological Process: ER-associated protein catabolic process; protein retention in ER; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; transmembrane transport
Reference #:  Q13438 (UniProtKB)
Alt. Names/Synonyms: Amplified in osteosarcoma 9; endoplasmic reticulum lectin 2; ERLEC2; erlectin 2; OS-9; OS9; osteosarcoma amplified 9, endoplasmic reticulum associated protein; osteosarcoma amplified 9, endoplasmic reticulum lectin; Protein OS-9
Gene Symbols: OS9
Molecular weight: 75,562 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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