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CUEDC2 Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism. May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression. Belongs to the CUEDC2 family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: cytosol; nuclear membrane; nucleoplasm
Molecular Function: protein binding
Reference #:  Q9H467 (UniProtKB)
Alt. Names/Synonyms: bA18I14.5; C10orf66; CUE domain containing 2; CUE domain-containing protein 2; CUED2; CUEDC2; MGC2491
Gene Symbols: CUEDC2
Molecular weight: 32,009 Da
Basal Isoelectric point: 4.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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