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METTL11A Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. Belongs to the methyltransferase superfamily. NTM1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Methyltransferase; Methyltransferase, protein N-term
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: histone methyltransferase activity; protein methyltransferase activity
Biological Process: chromosome segregation; histone methylation; N-terminal peptidyl-alanine methylation; N-terminal peptidyl-glycine methylation; N-terminal peptidyl-proline di-methylation; spindle organization and biogenesis
Reference #:  Q9BV86 (UniProtKB)
Alt. Names/Synonyms: AD-003; C9orf32; ME11A; methyltransferase like 11A; Methyltransferase-like protein 11A; METTL11A; NRMT; NTMT1
Gene Symbols: NTMT1
Molecular weight: 25,387 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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