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TLR1 Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 (via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: Golgi apparatus; integral component of plasma membrane; membrane; membrane raft; phagocytic vesicle membrane; plasma membrane
Molecular Function: protein binding; protein heterodimerization activity; receptor activity; transmembrane receptor activity
Biological Process: cell activation; defense response to bacterium; detection of triacylated bacterial lipoprotein; immune response; inflammatory response; innate immune response; macrophage activation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-6 biosynthetic process; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; signal transduction; toll-like receptor 1 signaling pathway; toll-like receptor signaling pathway
Disease: Leprosy, Susceptibility To, 5
Reference #:  Q15399 (UniProtKB)
Alt. Names/Synonyms: CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012; MGC104956; MGC126311; MGC126312; rsc786; TIL; TIL. LPRS5; TLR1; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein
Gene Symbols: TLR1
Molecular weight: 90,291 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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