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ENDOG Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. Homodimer. Belongs to the DNA/RNA non-specific endonuclease family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Deoxyribonuclease; EC 3.1.30.-; Mitochondrial; Ribonuclease
Chromosomal Location of Human Ortholog: 9q34.11
Molecular Function: protein binding
Biological Process: DNA fragmentation during apoptosis; DNA recombination
Reference #:  Q14249 (UniProtKB)
Alt. Names/Synonyms: Endo G; ENDOG; endonuclease G; Endonuclease G, mitochondrial; FLJ27463; NUCG
Gene Symbols: ENDOG
Molecular weight: 32,620 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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