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BRSK1 a serine/threonine protein kinase of the CAMK group. Closely related to AMPK. Activated by the kinase LKB1. Acts as checkpoint kinase upon DNA damage induced by UV or methyl methane sulfonate. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. Translocates from the cytoplasm to the nucleus in response to UV- or MMS-induced DNA damage. BRSK1 and BRSK2 are required for neuronal polarization. Widely expressed with highest levels in the brain and testis. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: BRSK subfamily; CAMK group; CAMKL family; EC; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: cell junction; centrosome; cytoplasm; nucleoplasm; nucleus; synaptic vesicle
Molecular Function: ATP binding; gamma-tubulin binding; magnesium ion binding; protein serine/threonine kinase activity; tau-protein kinase activity
Biological Process: axonogenesis; centrosome duplication; establishment of cell polarity; G2/M transition DNA damage checkpoint; neuron differentiation; neurotransmitter secretion; protein amino acid phosphorylation; response to DNA damage stimulus; response to ionizing radiation; response to UV
Reference #:  Q8TDC3 (UniProtKB)
Alt. Names/Synonyms: BR serine/threonine kinase 1; BR serine/threonine-protein kinase 1; BRSK1; FLJ43009; KIAA1811; protein kinase SAD1A; SAD1; SAD1 kinase; Serine/threonine-protein kinase SAD-B
Gene Symbols: BRSK1
Molecular weight: 85,087 Da
Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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