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BRIP1 a DNA-dependent ATPase and DNA helicase required for the maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Binds directly to the BRCT domains of BRCA1. Defects in BRIP1 cause of susceptibility to breast cancer and Fanconi anemia. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Belongs to the DEAD box helicase family, DEAH subfamily. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; Oncoprotein
Chromosomal Location of Human Ortholog: 17q23.2
Cellular Component: cytoplasm; nuclear membrane; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: DNA replication; DNA synthesis during DNA repair; regulation of transcription from RNA polymerase II promoter; strand displacement
Disease: Breast Cancer; Fanconi Anemia, Complementation Group J; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Reference #:  Q9BX63 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase BRIP1; BACH1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRIP1; FANCJ; Fanconi anemia group J protein; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ
Gene Symbols: BRIP1
Molecular weight: 140,878 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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