Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

SOS1 a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2, NCK, and other adapter proteins. Plays an important role in signaling pathways leading from the G-protein- coupled receptors and receptor tyrosine kinases to MAPK/ERK. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p22.1
Cellular Component: cytoplasm; cytosol; plasma membrane
Molecular Function: GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity
Biological Process: axon guidance; epidermal growth factor receptor signaling pathway; insulin receptor signaling pathway; leukocyte migration; MAPKKK cascade; positive regulation of apoptosis; Ras protein signal transduction; regulation of small GTPase mediated signal transduction
Disease: Fibromatosis, Gingival, 1; Noonan Syndrome 4
Reference #:  Q07889 (UniProtKB)
Alt. Names/Synonyms: GF1; GGF1; GINGF; gingival fibromatosis, hereditary, 1; HGF; NS4; Son of sevenless homolog 1; son of sevenless homolog 1 (Drosophila); SOS-1; SOS1
Gene Symbols: SOS1
Molecular weight: 152,464 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene