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PTP-PEST Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2. Interacts with TGFB1I1. Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: cytoplasm; cytosol
Molecular Function: non-membrane spanning protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; SH3 domain binding
Biological Process: protein amino acid dephosphorylation; regulation of epidermal growth factor receptor signaling pathway
Reference #:  Q05209 (UniProtKB)
Alt. Names/Synonyms: protein tyrosine phosphatase, non-receptor type 12; Protein-tyrosine phosphatase G1; PTN12; PTPG1; PTPN12; Tyrosine-protein phosphatase non-receptor type 12
Gene Symbols: PTPN12
Molecular weight: 88,106 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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