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Rab4 a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component: cytoplasmic vesicle membrane; early endosome membrane; endosome; perinuclear region of cytoplasm; vesicle
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding
Biological Process: antigen processing and presentation; phosphatidylinositol biosynthetic process; regulation of endocytosis
Reference #:  P20338 (UniProtKB)
Alt. Names/Synonyms: HRES-1/RAB4; Oncogene RAB4; RAB4; RAB4, member RAS oncogene family; RAB4A; RAB4A, member RAS oncogene family; Ras-related protein Rab-4A
Gene Symbols: RAB4A
Molecular weight: 24,390 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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