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GATA1 Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo. Interacts with EP300. Erythrocytes. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: nucleoplasm; nucleus; transcription factor complex; transcriptional repressor complex
Molecular Function: chromatin DNA binding; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: basophil differentiation; blood coagulation; eosinophil differentiation; erythrocyte development; erythrocyte differentiation; male gonad development; megakaryocyte differentiation; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; platelet formation; positive regulation of erythrocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter
Disease: Anemia, X-linked, With Or Without Neutropenia And/or Platelet Abnormalities; Down Syndrome; Thrombocytopenia With Beta-thalassemia, X-linked; Thrombocytopenia, X-linked, With Or Without Dyserythropoietic Anemia
Reference #:  P15976 (UniProtKB)
Alt. Names/Synonyms: ERYF1; Erythroid transcription factor; erythroid transcription factor 1; GATA binding protein 1 (globin transcription factor 1); GATA-1; GATA-binding factor 1; GATA1; GF-1; GF1; globin transcription factor 1; NF-E1 DNA-binding protein; NFE1; transcription factor GATA1; XLTT
Gene Symbols: GATA1
Molecular weight: 42,751 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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