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IGF2R a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.; Vesicle
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component: cell surface; clathrin coated vesicle membrane; early endosome; endocytic vesicle; endosome; focal adhesion; Golgi apparatus; integral to plasma membrane; late endosome; membrane; plasma membrane; secretory granule membrane; trans-Golgi network; trans-Golgi network membrane; trans-Golgi network transport vesicle; transport vesicle
Molecular Function: glycoprotein binding; identical protein binding; insulin-like growth factor receptor activity; phosphoprotein binding; protein binding; receptor activity
Biological Process: neutrophil degranulation; receptor-mediated endocytosis; signal transduction
Disease: Hepatocellular Carcinoma
Reference #:  P11717 (UniProtKB)
Alt. Names/Synonyms: 300 kDa mannose 6-phosphate receptor; cation-independent mannose-6 phosphate receptor; Cation-independent mannose-6-phosphate receptor; CD222; CI Man-6-P receptor; CI-MPR; CIMPR; IGF-II receptor; IGF2R; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6P-R; M6P/IGF2 receptor; M6P/IGF2R; M6PR; MPR 300; MPR1; MPRI
Gene Symbols: IGF2R
Molecular weight: 274,375 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
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