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G-alpha(z) Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); Nuclear envelope
Chromosomal Location of Human Ortholog: 22q11.22-q11.23
Cellular Component: endoplasmic reticulum; heterotrimeric G-protein complex; nuclear envelope; plasma membrane
Molecular Function: G-protein beta/gamma-subunit binding; G-protein-coupled receptor binding; GTP binding; GTPase activity; receptor signaling protein activity
Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; protein folding
Reference #:  P19086 (UniProtKB)
Alt. Names/Synonyms: G(x) alpha chain; GNAZ; guanine nucleotide binding protein (G protein), alpha z polypeptide; Guanine nucleotide-binding protein G(z) subunit alpha; Gz-alpha; transducin alpha
Gene Symbols: GNAZ
Molecular weight: 40,924 Da
Basal Isoelectric point: 7.53  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Phospholipase Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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