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FGF2 Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Activator; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4q28.1
Cellular Component: extracellular region; extracellular space
Molecular Function: 1-phosphatidylinositol-3-kinase activity; chemoattractant activity; cytokine activity; fibroblast growth factor receptor binding; growth factor activity; ligand-dependent nuclear receptor transcription coactivator activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: activation of MAPK activity; cell migration during sprouting angiogenesis; chemotaxis; embryonic morphogenesis; extracellular matrix organization and biogenesis; fibroblast growth factor receptor signaling pathway; growth factor dependent regulation of satellite cell proliferation; hyaluronan catabolic process; inositol phosphate biosynthetic process; MAPKKK cascade; negative regulation of blood vessel endothelial cell migration; nervous system development; organ morphogenesis; phosphatidylinositol biosynthetic process; phosphoinositide-mediated signaling; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cardiac muscle cell proliferation; positive regulation of cell fate specification; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of phosphoinositide 3-kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; regulation of angiogenesis; regulation of phosphoinositide 3-kinase cascade; release of sequestered calcium ion into cytosol; somatic stem cell maintenance; ureteric bud branching; wound healing
Reference #:  P09038 (UniProtKB)
Alt. Names/Synonyms: Basic fibroblast growth factor; basic fibroblast growth factor bFGF; BFGF; FGF2; FGFB; fibroblast growth factor 2; fibroblast growth factor 2 (basic); HBGF-2; Heparin-binding growth factor 2; prostatropin
Gene Symbols: FGF2
Molecular weight: 30,770 Da
Basal Isoelectric point: 11.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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