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ITGA6 Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Belongs to the integrin alpha chain family. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: basal plasma membrane; basement membrane; cell surface; cell-cell adherens junction; external side of plasma membrane; filopodium; focal adhesion; hemidesmosome; plasma membrane
Molecular Function: cadherin binding; insulin-like growth factor I binding; integrin binding; laminin binding; metal ion binding; protein binding
Biological Process: brown fat cell differentiation; cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; cellular response to extracellular stimulus; extracellular matrix organization; filopodium assembly; gut development; hemidesmosome assembly; integrin-mediated signaling pathway; leukocyte migration; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cell-cell adhesion; positive regulation of GTPase activity; positive regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; skin development
Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia
Reference #:  P23229 (UniProtKB)
Alt. Names/Synonyms: CD49 antigen-like family member F; CD49f; DKFZp686J01244; FLJ18737; Integrin alpha-6; Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; integrin alpha6B; integrin, alpha 6; ITA6; ITGA6; ITGA6B; VLA-6
Gene Symbols: ITGA6
Molecular weight: 126,606 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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