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Protein Page:

DYN2 a cytoplasmic microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. May mediate the conventional clathrin-mediated uptake of surface receptors. Expressed in the postsynaptic density of neuronal cells. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: coated pit; cytosol; focal adhesion; Golgi apparatus; Golgi membrane; growth cone; microtubule; mitochondrial membrane; plasma membrane; postsynaptic membrane
Molecular Function: GTPase activity; microtubule binding; protein binding; SH3 domain binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; mitochondrial fission; neurite morphogenesis; receptor internalization; receptor-mediated endocytosis; regulation of axon extension; regulation of nitric-oxide synthase activity; transferrin transport
Disease: Charcot-marie-tooth Disease, Dominant Intermediate B; Lethal Congenital Contracture Syndrome 5; Myopathy, Centronuclear, 1
Reference #:  P50570 (UniProtKB)
Alt. Names/Synonyms: CMT2M; CMTDI1; CMTDIB; DI-CMTB; DNM2; DYN2; dynamin 2; dynamin II; Dynamin-2; DYNII
Gene Symbols: DNM2
Molecular weight: 98,064 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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