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ITGAX Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cell surface; integrin complex; membrane; plasma membrane; secretory granule membrane
Molecular Function: metal ion binding; protein binding; receptor activity
Biological Process: cell adhesion; extracellular matrix organization; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte migration; neutrophil degranulation; organ morphogenesis
Disease: Systemic Lupus Erythematosus
Reference #:  P20702 (UniProtKB)
Alt. Names/Synonyms: CD11 antigen-like family member C; CD11C; Integrin alpha-X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); ITAX; ITGAX; Leu M5; leu M5, alpha subunit; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; myeloid membrane antigen, alpha subunit; p150 95 integrin alpha chain; SLEB6
Gene Symbols: ITGAX
Molecular weight: 127,829 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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