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SSTR1 Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Belongs to the G-protein coupled receptor 1 family. Interacts with SKB1. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 14q21.1
Cellular Component: integral to plasma membrane; neuron projection; plasma membrane
Molecular Function: neuropeptide binding; somatostatin receptor activity
Biological Process: cell surface receptor linked signal transduction; cell-cell signaling; digestion; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cell proliferation; response to nutrient
Reference #:  P30872 (UniProtKB)
Alt. Names/Synonyms: somatostatin receptor 1; Somatostatin receptor type 1; SRIF-2; SS-1-R; SS1-R; SS1R; SSR1; SSTR1
Gene Symbols: SSTR1
Molecular weight: 42,686 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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