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PHLDA3 p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor. Belongs to the PHLDA3 family. Induced by p53/TP53; expression is directly activated by p53/TP53. p53/TP53 phosphorylation on 'Ser-15' is required to activate the PHLDA3 promoter. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: plasma membrane
Molecular Function: phosphatidylinositol 3-phosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-5-phosphate binding
Biological Process: anatomical structure morphogenesis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of protein kinase B signaling cascade; positive regulation of apoptosis
Reference #:  Q9Y5J5 (UniProtKB)
Alt. Names/Synonyms: PHLA3; PHLDA3; Pleckstrin homology-like domain family A member 3; pleckstrin homology-like domain, family A, member 2; pleckstrin homology-like domain, family A, member 3; TDAG51/Ipl homolog 1; TIH1
Gene Symbols: PHLDA3
Molecular weight: 13,891 Da
Basal Isoelectric point: 9.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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