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Protein Page:

Epac1 Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, misc.
Chromosomal Location of Human Ortholog: 12q13.11
Cellular Component: cortical actin cytoskeleton; filopodium; lamellipodium; membrane; microvillus; plasma membrane
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein domain specific binding; Rap guanyl-nucleotide exchange factor activity
Biological Process: cell proliferation; positive regulation of angiogenesis; positive regulation of GTPase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein export from nucleus; positive regulation of stress fiber formation; positive regulation of syncytium formation by plasma membrane fusion; Rap protein signal transduction; regulation of insulin secretion; signal transduction
Reference #:  O95398 (UniProtKB)
Alt. Names/Synonyms: 9330170P05Rik; bcm910; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; CGEF1; EPAC; EPAC 1; EPAC1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; HSU79275; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; Rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; RAPGEF3; RPGF3
Gene Symbols: RAPGEF3
Molecular weight: 103,751 Da
Basal Isoelectric point: 7.28  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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