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CXCR5 Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: external side of plasma membrane; integral component of plasma membrane; plasma membrane
Molecular Function: C-X-C chemokine receptor activity; G-protein coupled receptor activity; protein binding
Biological Process: B cell activation; cell motility; G-protein coupled receptor signaling pathway; immune response; leukocyte chemotaxis; lymph node development; positive regulation of cytokinesis
Reference #:  P32302 (UniProtKB)
Alt. Names/Synonyms: BLR1; Burkitt lymphoma receptor 1; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; C-X-C chemokine receptor type 5; CD185; chemokine (C-X-C motif) receptor 5; CXC-R5; CXCR-5; CXCR5; MDR-15; MDR15; MGC117347; Monocyte-derived receptor 15
Gene Symbols: CXCR5
Molecular weight: 41,955 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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