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Protein Page:

LAG3 a cell surface receptor involved in lymphocyte activation and neural function. LAG3 expressed on neurons is a receptor that binds extracellular Alpha-synuclein fibrils (PFF) with high affinity, leading to its endocytosis. LAG3 facilitates the neuron-to-neuron spread of PFF and its associated neural toxicity. Binds to HLA class-II antigens. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: external side of plasma membrane; integral component of membrane; plasma membrane
Molecular Function: antigen binding; MHC class II protein binding; transmembrane receptor activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cell surface receptor signaling pathway; negative regulation of interleukin-2 biosynthetic process; negative regulation of T cell activation; positive regulation of natural killer cell mediated cytotoxicity
Reference #:  P18627 (UniProtKB)
Alt. Names/Synonyms: CD223; FDC; LAG-3; LAG3; Lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Protein FDC
Gene Symbols: LAG3
Molecular weight: 57,449 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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