Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

CAPN2 Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: chromatin; cortical actin cytoskeleton; cytoplasm; cytosol; dendrite; endoplasmic reticulum; extracellular exosome; focal adhesion; Golgi apparatus; lysosome; membrane raft; nucleus; plasma membrane; pseudopodium
Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cysteine-type peptidase activity; cytoskeletal protein binding; protein binding; protein heterodimerization activity
Biological Process: blastocyst development; extracellular matrix disassembly; myoblast fusion; protein autoprocessing; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of cytoskeleton organization; response to hypoxia
Reference #:  P17655 (UniProtKB)
Alt. Names/Synonyms: Calcium-activated neutral proteinase 2; Calpain 2; calpain 2, (m/II) large subunit; calpain 2, large [catalytic] subunit; calpain 2, large subunit; Calpain large polypeptide L2; Calpain M-type; calpain, large polypeptide L2; Calpain-2; Calpain-2 catalytic subunit; Calpain-2 large subunit; CAN2; CANP 2; CANP2; CANPL2; CANPml; CAPN2; FLJ39928; M-calpain; mCANP; Millimolar-calpain
Gene Symbols: CAPN2
Molecular weight: 79,995 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein