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DAT Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI). It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 5p15.33
Cellular Component: axon; cell soma; cell surface; cytoplasm; flotillin complex; integral component of membrane; integral component of plasma membrane; membrane raft; neuron projection; plasma membrane
Molecular Function: dopamine binding; dopamine transmembrane transporter activity; dopamine:sodium symporter activity; drug binding; metal ion binding; monoamine transmembrane transporter activity; protease binding; protein binding; protein complex binding; protein N-terminus binding; protein phosphatase 2A binding; receptor binding
Biological Process: adenohypophysis development; aging; dopamine biosynthetic process; dopamine catabolic process; dopamine transport; dopamine uptake; lactation; locomotory behavior; monoamine transport; neurotransmitter biosynthetic process; positive regulation of multicellular organism growth; prepulse inhibition; regulation of dopamine metabolic process; response to cAMP; response to cocaine; response to drug; response to ethanol; response to iron ion; response to nicotine; sensory perception of smell
Disease: Parkinsonism-dystonia, Infantile; Tobacco Addiction, Susceptibility To
Reference #:  Q01959 (UniProtKB)
Alt. Names/Synonyms: DA transporter; DAT; DAT1; SC6A3; SLC6A3; Sodium-dependent dopamine transporter; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Solute carrier family 6 member 3
Gene Symbols: SLC6A3
Molecular weight: 68,495 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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