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PTPN2 a type 2 non-receptor phospho-tyrosine-protein phosphatase (PTP). Two alternatively spliced isoforms are differenyially expressed. Isoform A is a major PTP expressed in human tissues, while isoform B is expressed mainly in T-cells and in placenta. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 18p11.21
Cellular Component: cytosol; endoplasmic reticulum; ER-Golgi intermediate compartment; nucleoplasm; plasma membrane
Molecular Function: integrin binding; protein binding; protein kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; syntaxin binding
Biological Process: B cell differentiation; erythrocyte differentiation; glucose homeostasis; insulin receptor signaling pathway; negative regulation of cell proliferation; negative regulation of chemotaxis; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of macrophage differentiation; negative regulation of T cell receptor signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; positive regulation of gluconeogenesis; T cell differentiation
Reference #:  P17706 (UniProtKB)
Alt. Names/Synonyms: protein tyrosine phosphatase, non-receptor type 2; PTN2; PTPN2; PTPT; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TC-PTP; TCELLPTP; TCPTP; Tyrosine-protein phosphatase non-receptor type 2
Gene Symbols: PTPN2
Molecular weight: 48,473 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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