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fascin Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Associates with beta-catenin. Ubiquitous. Belongs to the fascin family. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7p22.1
Cellular Component: actin cytoskeleton; cell projection membrane; cytoplasm; cytoskeleton; cytosol; filamentous actin; filopodium; growth cone; intercellular junction; lamellipodium; microvillus; podosome; ruffle; stress fiber
Molecular Function: actin binding; actin filament binding; cadherin binding; drug binding; protein binding; RNA binding
Biological Process: actin cytoskeleton organization and biogenesis; actin filament bundle formation; anatomical structure morphogenesis; cell migration; cell motility involved in cell locomotion; cell proliferation; establishment of apical/basal cell polarity; intercellular junction assembly; microspike biogenesis; positive regulation of filopodium formation; regulation of actin cytoskeleton organization and biogenesis; regulation of microvillus biogenesis
Reference #:  Q16658 (UniProtKB)
Alt. Names/Synonyms: 55 kDa actin-bundling protein; actin bundling protein; FAN1; Fascin; fascin 1; fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus); FLJ38511; FSCN1; HSN; p55; Singed, drosophila, homolog-like; singed-like (fascin homolog, sea urchin); Singed-like protein; SNL
Gene Symbols: FSCN1
Molecular weight: 54,530 Da
Basal Isoelectric point: 6.84  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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