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FKBP4 Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. Note: This description may include information from UniProtKB.
Protein type: Chaperone; EC; Isomerase
Chromosomal Location of Human Ortholog: 12p13.33
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: FK506 binding; heat shock protein binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein binding, bridging; RNA binding
Biological Process: negative regulation of microtubule polymerization or depolymerization; protein folding
Reference #:  Q02790 (UniProtKB)
Alt. Names/Synonyms: 52 kD FK506 binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4, 59kDa; FK506 binding protein 52; FK506-binding protein 4; FK506-binding protein 4 (59kD); FKBP-4; FKBP-52; FKBP4; FKBP52; FKBP59; HBI; HSP binding immunophilin; HSP-binding immunophilin; Hsp56; Immunophilin FKBP52; p52; p59; p59 protein; Peptidyl-prolyl cis-trans isomerase FKBP4; Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; peptidylprolyl cis-trans isomerase; PPIase FKBP4; T-cell FK506-binding protein, 59kD
Gene Symbols: FKBP4
Molecular weight: 51,805 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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