Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

AFAP1L2 May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: cytoplasm; cytosol; plasma membrane
Molecular Function: protein tyrosine kinase activator activity; SH2 domain binding; SH3 domain binding
Biological Process: inflammatory response; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of transcription, DNA-dependent; regulation of interleukin-6 production; regulation of mitotic cell cycle
Reference #:  Q8N4X5 (UniProtKB)
Alt. Names/Synonyms: actin filament associated protein 1-like 2; Actin filament-associated protein 1-like 2; AF1L2; AFAP1-like protein 2; AFAP1L2; CTB-1144G6.4; FLJ14564; KIAA1914; XB130
Gene Symbols: AFAP1L2
Molecular weight: 91,300 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein