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NDRG2 a pro-apoptotic protein that may be involved in dendritic cell and neuron differentiation. May have anti-tumor activity. Generally not expressed in tumor cell lines. Unlike Ndr1, Ndr2 and Ndr3 appear not to be controlled by N-myc or c-myc. The loss of NDRG2 expression has been shown to be a prognostic indicator in gastric carcinomas. Five isoforms of the human protein are produced by alternative splicing. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Tumor suppressor
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: cytoplasm; Golgi apparatus
Molecular Function: protein binding
Biological Process: signal transduction; substantia nigra development
Reference #:  Q9UN36 (UniProtKB)
Alt. Names/Synonyms: cytoplasmic protein Ndr1; DKFZp781G1938; FLJ25522; KIAA1248; N-myc downstream regulator 2; NDR1-related protein NDR2; NDRG family member 2; NDRG2; Protein NDRG2; Protein Syld709613; SYLD; syld709613 protein
Gene Symbols: NDRG2
Molecular weight: 40,798 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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