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CD44 Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 11p13
Cellular Component: apical plasma membrane; cell projection; cell surface; cytosol; focal adhesion; Golgi apparatus; integral component of plasma membrane; plasma membrane; secretory granule membrane
Molecular Function: collagen binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; hyaluronic acid binding; protein binding
Biological Process: cartilage development; cell-matrix adhesion; extracellular matrix disassembly; extracellular matrix organization; hyaluronan catabolic process; leukocyte migration; negative regulation of apoptosis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; neutrophil degranulation; positive regulation of heterotypic cell-cell adhesion; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation
Disease: Blood Group, Indian System
Reference #:  P16070 (UniProtKB)
Alt. Names/Synonyms: antigen gp90 homing receptor; CD44; CD44 antigen; CD44 antigen (homing function and Indian blood group system); CD44 molecule (Indian blood group); CDw44; CDW44 antigen; cell adhesion molecule; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; CSPG8; ECMR-III; Epican; Extracellular matrix receptor III; extracellular matrix receptor-III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; Hyaluronate receptor; IN; LHR; MC56; MDU2; MDU3; MGC10468; MIC4; MUTCH-I; PGP-1; PGP-I; Pgp1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I
Gene Symbols: CD44
Molecular weight: 81,538 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
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