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ACC2 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Activity is increased by oligomerization. Activated by citrate. Citrate and MID1IP1 promote oligomerization. Inhibited by malonyl-CoA. ACC1 is the predominant form expressed in liver, adipocyte and mammary gland. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC2 is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC; EC; Ligase; Lipid Metabolism - fatty acid biosynthesis; Mitochondrial
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: cytosol; mitochondrial outer membrane; mitochondrion; nucleus
Molecular Function: acetyl-CoA carboxylase activity; protein binding
Biological Process: acetyl-CoA metabolic process; biotin metabolic process; carnitine shuttle; positive regulation of cellular metabolic process; protein homotetramerization; regulation of cholesterol biosynthetic process
Reference #:  O00763 (UniProtKB)
Alt. Names/Synonyms: ACACB; ACC-beta; ACC2; ACCB; Acetyl-CoA carboxylase 2; acetyl-Coenzyme A carboxylase beta; Biotin carboxylase; HACC275
Gene Symbols: ACACB
Molecular weight: 276,541 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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