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Protein Page:

TAL1 a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 1p33
Cellular Component: histone deacetylase complex; nuclear chromatin; nucleus; transcription factor complex
Molecular Function: chromatin binding; enzyme binding; histone deacetylase binding; protein binding; transcription factor activity
Biological Process: basophil differentiation; cell fate commitment; embryonic hemopoiesis; erythrocyte differentiation; hemopoiesis; megakaryocyte differentiation; positive regulation of cell division; positive regulation of chromatin assembly or disassembly; positive regulation of erythrocyte differentiation; positive regulation of mitotic cell cycle; positive regulation of protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter
Disease: Leukemia, Acute Lymphoblastic
Reference #:  P17542 (UniProtKB)
Alt. Names/Synonyms: BHLHA17; Class A basic helix-loop-helix protein 17; SCL; Stem cell protein; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; TAL-1; tal-1 product; TAL1; TCL5
Gene Symbols: TAL1
Molecular weight: 34,271 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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