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IQGAP1 Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6. Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: actin cytoskeleton; actin filament; axon; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; growth cone; microtubule; microtubule cytoskeleton; midbody; neuron projection; plasma membrane; ruffle; secretory granule membrane
Molecular Function: cadherin binding; calcium ion binding; GTPase activator activity; GTPase inhibitor activity; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activator activity
Biological Process: epidermal growth factor receptor signaling pathway; neutrophil degranulation; positive regulation of protein kinase activity; signal transduction
Reference #:  P46940 (UniProtKB)
Alt. Names/Synonyms: HUMORFA01; IQ motif containing GTPase activating protein 1; IQGA1; IQGAP1; KIAA0051; p195; Ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs; SAR1
Gene Symbols: IQGAP1
Molecular weight: 189,252 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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