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PGAM1 Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC (synthase) and EC (phosphatase), but with a reduced activity. Homodimer. In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC; EC; EC; Isomerase; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 10q24.1
Cellular Component: cytoplasm; cytosol; extracellular region; membrane
Molecular Function: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; phosphoglycerate mutase activity; protein binding; protein kinase binding
Biological Process: gluconeogenesis; glycolysis; neutrophil degranulation; regulation of glycolysis; regulation of pentose-phosphate shunt; respiratory burst
Reference #:  P18669 (UniProtKB)
Alt. Names/Synonyms: BPG-dependent PGAM 1; PGAM-B; PGAM1; PGAMA; Phosphoglycerate mutase 1; phosphoglycerate mutase 1 (brain); phosphoglycerate mutase A, nonmuscle form; Phosphoglycerate mutase isozyme B
Gene Symbols: PGAM1
Molecular weight: 28,804 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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