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EPS15 Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits. Interacts with SGIP1. Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM1 or STAM2. Binds AP2A2. Interacts with AP2B1; clathrin competes with EPS15. Binds STON2 and EPN1. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP. Interacts with ERBB2. Interacts with FCHO1. Interacts with FCHO2. Ubiquitously expressed. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Oncoprotein; Vesicle
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: coated pit; cytosol; intracellular membrane-bound organelle; membrane; plasma membrane
Molecular Function: cadherin binding; polyubiquitin binding; protein binding
Biological Process: cell proliferation; clathrin cage assembly; endocytic recycling; entry of virus into host cell; epidermal growth factor receptor signaling pathway; Golgi to endosome transport; negative regulation of epidermal growth factor receptor signaling pathway; receptor mediated endocytosis of virus by host; vesicle organization and biogenesis
Reference #:  P42566 (UniProtKB)
Alt. Names/Synonyms: AF-1P; AF1P; ALL1 fused gene from chromosome 1; epidermal growth factor receptor pathway substrate 15; Epidermal growth factor receptor substrate 15; EPS15; MLLT5; Protein AF-1p; Protein Eps15
Gene Symbols: EPS15
Molecular weight: 98,656 Da
Basal Isoelectric point: 4.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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