a transcription factor of the ikaros C2H2-type zinc-finger protein family. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Deletions in Ikaros have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Seven alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus; protein complex
Molecular Function: DNA binding; protein binding; protein domain specific binding; transcription factor activity
Biological Process: erythrocyte differentiation; lymphocyte differentiation; mesoderm development; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; protein heterooligomerization