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Ikaros a transcription factor of the ikaros C2H2-type zinc-finger protein family. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Deletions in Ikaros have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Seven alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 7p12.2
Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus; protein complex
Molecular Function: DNA binding; protein binding; protein domain specific binding; transcription factor activity
Biological Process: erythrocyte differentiation; lymphocyte differentiation; mesoderm development; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; protein heterooligomerization
Disease: Immunodeficiency, Common Variable, 13
Reference #:  Q13422 (UniProtKB)
Alt. Names/Synonyms: CLL-associated antigen KW-6; DNA-binding protein Ikaros; hIk-1; Hs.54452; IK1; IKAROS; Ikaros (zinc finger protein); IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; IKZF1; LYF1; Lymphoid transcription factor LyF-1; PRO0758; zinc finger protein, subfamily 1A, 1 (Ikaros); ZNFN1A1
Gene Symbols: IKZF1
Molecular weight: 57,528 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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