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IL2RB Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Belongs to the type I cytokine receptor family. Type 4 subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: cytosol; endosome; external side of plasma membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function: interleukin-2 binding; interleukin-2 receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: cytokine-mediated signaling pathway; interleukin-2-mediated signaling pathway; MAPK cascade; negative regulation of apoptosis; protein complex assembly; regulation of molecular function; signal transduction; viral process
Reference #:  P14784 (UniProtKB)
Alt. Names/Synonyms: CD122; CD122 antigen; high affinity IL-2 receptor beta subunit; High affinity IL-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; IL2RB; interleukin 2 receptor, beta; Interleukin-2 receptor subunit beta; p70-75; p75
Gene Symbols: IL2RB
Molecular weight: 61,117 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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