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LSM2 Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing. Identified in the spliceosome C complex. LSm subunits form a heteromer with a doughnut shape. Belongs to the snRNP Sm proteins family. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 6p21.33
Cellular Component: cytosol; nucleoplasm; U4/U6 x U5 tri-snRNP complex
Molecular Function: protein binding; Ral GTPase binding; RNA binding
Biological Process: nuclear mRNA splicing, via spliceosome
Reference #:  Q9Y333 (UniProtKB)
Alt. Names/Synonyms: C6orf28; G7B; LSM2; LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae); Protein G7b; Small nuclear ribonuclear protein D homolog; snRNP; snRNP core Sm-like protein Sm-x5; U6 snRNA-associated Sm-like protein LSm2; YBL026W
Gene Symbols: LSM2
Molecular weight: 10,835 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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