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DICER1 a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; EC; Helicase; RNA processing; RNA-binding; Ribonuclease
Chromosomal Location of Human Ortholog: 14q32.13
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: deoxyribonuclease I activity; double-stranded RNA binding; endoribonuclease activity; protein binding; protein domain specific binding; ribonuclease III activity; siRNA binding
Biological Process: DNA fragmentation during apoptosis; miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, production of miRNAs; myelin formation in the peripheral nervous system; negative regulation of transcription from RNA polymerase II promoter; nerve development; neurite morphogenesis; positive regulation of myelination; positive regulation of Schwann cell differentiation; pre-microRNA processing; RNA interference, conversion of ds siRNA to ss siRNA; RNA interference, production of siRNA; RNA interference, siRNA loading onto RISC; RNA interference, targeting of mRNA for destruction
Disease: Goiter, Multinodular 1, With Or Without Sertoli-leydig Cell Tumors; Pleuropulmonary Blastoma; Rhabdomyosarcoma, Embryonal, 2
Reference #:  Q9UPY3 (UniProtKB)
Alt. Names/Synonyms: DCR1; DICER; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease type III; DICER1; Dicer1, Dcr-1 homolog; Endoribonuclease Dicer; Helicase MOI; Helicase with RNase motif; helicase-moi; HERNA; K12H4.8-LIKE; KIAA0928
Gene Symbols: DICER1
Molecular weight: 218,682 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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