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Protein Page:

BAP37 a protein of the band 7 family. This family includes the prohibitins, cytoplasmic anti-proliferative proteins and stomatin, an erythrocyte membrane protein. A repressor of estrogen receptor (ER) activity. Reverses steroid receptor coactivator 1 enhancement of ER activity. May play a role in determining the sensitivity of estrogen target cells to antiestrogen and estrogen therapy. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: cell surface; cytoplasm; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrion; nuclear matrix; nucleus; protein complex
Molecular Function: amide binding; protein binding; protein C-terminus binding; protein N-terminus binding
Biological Process: mitochondrial calcium ion transport; mitochondrion organization and biogenesis; negative regulation of apoptosis; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of exit from mitosis; positive regulation of transcription factor activity; protein import into nucleus, translocation; protein stabilization; regulation of complement activation; sister chromatid cohesion
Reference #:  Q99623 (UniProtKB)
Alt. Names/Synonyms: B-cell associated protein; B-cell receptor-associated protein BAP37; BAP; Bap37; BCAP37; D-prohibitin; MGC117268; p22; PHB2; PNAS-141; prohibitin 2; Prohibitin-2; REA; Repressor of estrogen receptor activity
Gene Symbols: PHB2
Molecular weight: 33,296 Da
Basal Isoelectric point: 9.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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