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Protein Page:

GCN5 an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: extracellular space; nucleoplasm; nucleus
Molecular Function: H3 histone acetyltransferase activity; histone acetyltransferase activity; histone deacetylase binding; protein binding; transcription coactivator activity; transcription factor binding
Biological Process: chromatin remodeling; histone deubiquitination; positive regulation of gene expression, epigenetic; protein deubiquitination; regulation of protein stability; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Reference #:  Q92830 (UniProtKB)
Alt. Names/Synonyms: GCN5; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; GCN5L2; General control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis, yeast, homolog-like 2; HGCN5; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; HsGCN5; K(lysine) acetyltransferase 2A; KAT2A; Lysine acetyltransferase 2A; MGC102791; PCAF-b; STAF97
Gene Symbols: KAT2A
Molecular weight: 93,926 Da
Basal Isoelectric point: 9.18  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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