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TRXR1 a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity. Note: This description may include information from UniProtKB.
Protein type: EC; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Oxidoreductase
Chromosomal Location of Human Ortholog: 12q23.3
Cellular Component: cytosol; fibrillar center; mitochondrion; nucleoplasm
Molecular Function: protein binding; thioredoxin-disulfide reductase activity
Biological Process: cell redox homeostasis; nucleobase, nucleoside and nucleotide interconversion; regulation of lipid metabolic process; response to oxygen radical; selenium metabolic process
Reference #:  Q16881 (UniProtKB)
Alt. Names/Synonyms: Gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; GRIM12; KDRF; KM-102-derived reductase-like factor; MGC9145; oxidoreductase; thioredoxin reductase 1; Thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; Thioredoxin reductase TR1; TR1; TRXR1; TXNR; TXNRD1
Gene Symbols: TXNRD1
Molecular weight: 70,906 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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