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Protein Page:

TRIM25 a ubiquitous protein that mediates estrogen action in various target organs. Contains one RING-type zinc finger and one SPRY domain.. Note: This description may include information from UniProtKB.
Protein type: EC; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: cytosol; nuclear body; nucleoplasm
Molecular Function: cadherin binding; protein binding; RNA binding; transcription factor activity; ubiquitin-protein ligase activity
Biological Process: activation of NF-kappaB transcription factor; bypass DNA synthesis; innate immune response; negative regulation of interferon type I production; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity; protein deubiquitination; protein monoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of virion penetration into host cell; response to estrogen stimulus
Reference #:  Q14258 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin/ISG15 ligase TRIM25; EFP; Estrogen-responsive finger protein; RING finger protein 147; RNF147; TRI25; TRIM25; tripartite motif protein TRIM25; tripartite motif-containing 25; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Z147; Zinc finger protein 147; zinc finger protein 147 (estrogen-responsive finger protein); zinc finger protein-147; ZNF147
Gene Symbols: TRIM25
Molecular weight: 70,973 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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