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TIAL1 a member of a family of RNA-binding proteins that possesses nucleolytic activity. A cytotoxic T cell granule-associated protein that has been shown to bind specifically to poly(A) homopolymers and to fragment DNA in permeabilized target cells. Members of this protein family may be involved in the induction of apoptosis. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; RNA-binding
Chromosomal Location of Human Ortholog: 10q26.11
Cellular Component: cytoplasm; lysosome; nucleoplasm; nucleus; stress granule
Molecular Function: RNA binding
Biological Process: defense response; fibroblast growth factor receptor signaling pathway; regulation of transcription from RNA polymerase II promoter
Reference #:  Q01085 (UniProtKB)
Alt. Names/Synonyms: aging-associated gene 7 protein; MGC33401; Nucleolysin TIAR; T-cluster binding protein; TCBP; TIA-1 related protein; TIA-1-related nucleolysin; TIA-1-related protein; TIA1 cytotoxic granule-associated RNA binding protein-like 1; TIA1 cytotoxic granule-associated RNA-binding protein-like 1; TIAL1; TIAR
Gene Symbols: TIAL1
Molecular weight: 41,591 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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